| 2,251 | 16 | 1438 |
| 下载次数 | 被引频次 | 阅读次数 |
综述了对葡萄糖具有良好的催化效应且被广泛用于葡萄糖传感器研发当中的葡萄糖氧化酶(GOx)在葡萄糖传感器酶电极中的固定化方法,并分析其对葡萄糖传感器性能的影响;根据连续监测形式将葡萄糖传感器划分成微创式、植入式和无创式,归纳总结了采用不同监测形式的葡萄糖传感器的最新研究进展;最后,对基于GOx的葡萄糖传感器在柔性可穿戴领域的发展前景进行了展望。
Abstract：The glucose oxidase(GOx) is widely used in the research and development of glucose sensors because of its good catalytic effect on glucose. The GOx immobilization methods in enzyme electrode of glucose sensor and its effects on the performance of glucose sensors are reviewed. The glucose sensor is classified into minimally invasive, implantable and non-invasive according to its continuous monitoring form. The latest research progress of glucose sensor with different monitoring form is summarized. Finally, the development prospect of GOx-based glucose sensor in the field of flexible wearables is prospected.
[1] SONG J Y,HE W T,SHEN H,et al. Self-assembly of a magnetic DNA hydrogel as a new biomaterial for enzyme encapsulation with enhanced activity and stability[J]. Chemical Communications,2019,55(17):2449-2452.
[2] BUCKINGHAM B,HIRSCH I,HUANG E S. Continuous glucose monitoring and intensive treatment of type 1 diabetes[J].New England Journal of Medicine,2008,359(14):1464-1476.
[3] SANGHERA N,ANDERSON A,NUAR N,et al. Insulin biosensor development:A case study[J]. International Journal of Parallel,Emergent and Distributed Systems(Special Issue:Signal Processing,Biosensing,and Computing with Bio-inspired and Biochemical Systems),2017,32(1):119-138.
[4]石文韬，邸静，马占芳.电化学葡萄糖传感器[J].化学进展，2012,24(4):568-576.SHI W T,DI J,MA Z F. Electrochemical glucose biosensors[J].Progress in Chemistry,2012,24(4):568-576(in Chinese).
[5] WONG C M,WONG K H,CHEN X D. Glucose oxidase:Natural occurrence,function,properties and industrial applications[J]. Applied Microbiology and Biotechnology,2008,78(6):927-938.
[6] UPDIKE S J,HICKS G P. The enzyme electrode[J]. Nature,1967,214(5092):986-988.
[7] HELLER A,FELDMAN B. Electrochemical glucose sensors and their applications in diabetes management[J]. Chemical Reviews,2008,108(7):2482-2505.
[8] LI X Y,DU X Z. Molybdenum disulfide nanosheets supported Au-Pd bimetallic nanoparticles for non-enzymatic electrochemical sensing of hydrogen peroxide and glucose[J]. Sensors and Actuators B:Chemical,2017,239:536-543.
[9] YANG J,ZHANG W D,GUNASEKARAN S. An amperometric non-enzymatic glucose sensor by electrodepositing copper nanocubes onto vertically well-aligned multi-walled carbon nanotube arrays[J]. Biosensors and Bioelectronics,2010,26(1):279-284.
[10] SALIMI A,SHARIFI E,NOORBAKHSH A,et al. Immobilization of glucose oxidase on electrodeposited nickel oxide nanoparticles:Direct electron transfer and electrocatalytic activity[J]. Biosensors and Bioelectronics,2007,22(12):3146-3153.
[11] KANG X H,MAI Z B,ZOU X Y,et al. A novel glucose biosensor based on immobilization of glucose oxidase in chitosan on a glassy carbon electrode modified with gold-platinum alloy nanoparticles/multiwall carbon nanotubes[J]. Analytical Biochemistry,2007,369(1):71-79.
[12] CHO J H,SHIN M C,KIM H S. Electrochemical adsorption of glucose oxidase onto polypyrrole film for the construction of a glucose biosensor[J]. Sensors and Actuators B:Chemical,1996,30(2):137-141.
[13] PALOD P A,PANDEY S S,HAYASE S,et al. Template-assisted electrochemical growth of polypyrrole nanotubes for development of high sensitivity glucose biosensor[J]. Applied Biochemistry and Biotechnology,2014,174(3):1059-1072.
[14] LI J,BI X,TAMULEVI GˇIUS S,et al. Fabrication of a biocompatible and continuous glucose biosensor with the poly(3,4-ethylenedioxythiophene)modified electrode[J]. Journal of the Taiwan Institute of Chemical Engineers,2019,104:1-7.
[15] YOON J,LEE S N,SHIN M K,et al. Flexible electrochemical glucose biosensor based on GOx/gold/MoS2/gold nanofilm on the polymer electrode[J]. Biosensors and Bioelectronics,2019,140:111343.
[16] VESALINASEH M,MORTAZAVI Y,KHODADADI A A,et al. Plasma thiol-functionalized carbon nanotubes decorated with gold nanoparticles for glucose biosensor[J]. Sensors and Actuators B:Chemical,2013,188:488-495.
[17] SHUAI Y,LIU C H,WANG J,et al. Pseudo-bi-enzyme glucose sensor:ZnS hollow spheres and glucose oxidase concerted catalysis glucose[J]. The Analyst,2013,138(11):3259-3263.
[18] ZHOU F,JING W X,LIU S,et al. Electrodeposition of gold nanoparticles on Zn O nanorods for improved performance of enzymatic glucose sensors[J]. Materials Science in Semiconductor Processing,2020,105:104708.
[19] TIAN K J,LIU H,DONG Y P,et al. Amperometric detection of glucose based on immobilizing glucose oxidase on g-C3N4nanosheets[J]. Colloids and Surfaces A:Physicochemical and Engineering Aspects,2019,581:123808.
[20]赵琨，孟阿兰. Nafion/GOx/CS-g-C3N4/GCE的制备及其在葡萄糖生物传感器中的应用[J].青岛科技大学学报（自然科学版），2018,39(5):15-20,26.ZHAO K,MENG A L. Preparation of nafion/GOx/CS-g-C3N4/GCE and its application in glucose biosensor[J]. Journal of Qingdao University of Science and Technology(Natural Science Edition),2018,39(5):15-20,26(in Chinese).
[21] VUKOJEVI'C V,DJURDJI'C S,OGNJANOVI'C M,et al. Enzymatic glucose biosensor based on manganese dioxide nanoparticles decorated on graphene nanoribbons[J]. Journal of Electroanalytical Chemistry,2018,823:610-616.
[22] MIAO Z L,WANG P Y,ZHONG A M,et al. Development of a glucose biosensor based on electrodeposited gold nanoparticles-polyvinylpyrrolidone-polyaniline nanocomposites[J].Journal of Electroanalytical Chemistry,2015,756:153-160.
[23] HOU C,ZHAO D Y,WANG Y,et al. Preparation of magnetic Fe3O4/PPy@ZIF-8 nanocomposite for glucose oxidase immobilization and used as glucose electrochemical biosensor[J]. Journal of Electroanalytical Chemistry,2018,822:50-56.
[24] LEE S Y,YOON H H. Immobilization of glucose oxidase within chitosan and sol-gel matrix for biosensors[J]. Molecular Crystals and Liquid Crystals,2012,566(1):38-44.
[25] DHANJAI,LU X B,WU L X,et al. Robust single-molecule enzyme nanocapsules for biosensing with significantly improved biosensor stability[J]. Analytical Chemistry,2020,92(8):5830-5837.
[26] SANTANA J L,M魣RQUEZ L A,OSUNA V,et al. Nakedeye detection of glucose in saliva with bienzymatic paperbased sensor[J]. Sensors,2018,18(4):1071.
[27] BAGAL K D R,CHIANG B H. Platinum nanoparticle-carbon nanotubes dispersed in gum arabic-corn flour composite-enzymes for an electrochemical sucrose sensing in commercial juice[J]. Ionics,2019,25(11):5551-5564.
[28] KIM D M,CHO S J,CHO C H,et al. Disposable all-solidstate pH and glucose sensors based on conductive polymer covered hierarchical AuZn oxide[J]. Biosensors and Bioelectronics,2016,79:165-172.
[29] DEBASIS M,MINITHA C R,RAJENDRA K R T. Glucose oxidase immobilized amine terminated multiwall carbon nanotubes/reduced graphene oxide/polyaniline/gold nanoparticles modified screen-printed carbon electrode for highly sensitive amperometric glucose detection[J]. Materials Science and Engineering:C,2019,105:110075.
[30] MATYSIAK B E,SK J P,KASPRZAK A,et al. Reduced graphene oxide doping with nanometer-sized ferrocene moietiesnew active material for glucose redox sensors[J]. Biosensors and Bioelectronics,2019. 128:23-31.
[31] ALSAGUR H,KOMATHI S,KHAN M A,et al. A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel[J]. Biosensors and Bioelectronics,2017,92:638-645.
[32] CHAICHI M J,EHSANI M. A novel glucose sensor based on immobilization of glucose oxidase on the chitosan-coated Fe3O4nanoparticles and the luminol-H2O2-gold nanoparticle chemiluminescence detection system[J]. Sensors and Actuators B:Chemical,2016,223:713-722.
[33] HIMURO Y,TAKAI M,ISHIHARA K. Poly(vinylferroceneco-2-hydroxyethyl methacrylate)mediator as immobilized enzyme membrane for the fabrication of amperometric glucose sensor[J]. Sensors and Actuators B:Chemical,2009,136(1):122-127.
[34] FANG L,LIANG B,YANG G,et al. A needle-type glucose biosensor based on PANI nanofibers and PU/E-PU membrane for long-term invasive continuous monitoring[J]. Biosensors and Bioelectronics,2017,97:196-202.
[35] XU H,MALLADI K,WANG C L,et al. Carbon post-microarrays for glucose sensors[J]. Biosensors and Bioelectronics,2008,23(11):1637-1644.
[36] WU H Y,LEE C J,WANG H F,et al. Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene)(PSBEDOT)glucose biosensor[J]. Chemical Science,2018,9(9):2540-2546.
[37] JDRZAK A,TOMASZ R,LUKASZ K,et al. Carbon paste electrode based on functional GOx/silica-lignin system to prepare an amperometric glucose biosensor[J]. Sensors and Actuators B:Chemical,2018,256:176-185.
[38] XU S,ZHANG Y H,ZHU Y,et al. Facile one-step fabrication of glucose oxidase loaded polymeric nanoparticles decorating MWCNTs for constructing glucose biosensing platform:Structure matters[J]. Biosensors and Bioelectronics,2019,135:153-159.
[39] KAFI A K M,ALIM S,JOSE R,et al. Fabrication of a glucose oxidase/multiporous tin-oxide nanofiber film on Prussian blue-modified gold electrode for biosensing[J]. Journal of Electroanalytical Chemistry,2019,852:113550.
[40] MANSOURI N,BABADI A A,BAGHERI S,et al. Immobilization of glucose oxidase on 3D graphene thin film:Novel glucose bioanalytical sensing platform[J]. International Journal of Hydrogen Energy,2017,42(2):1337-1343.
[41] SHIN D H,KIM W,JUN J,et al. Highly selective FET-type glucose sensor based on shape-controlled palladium nanoflower-decorated graphene[J]. Sensors and Actuators B:Chemical,2018,264:216-223.
[42] KUWAHARA T,OGAWA K,SUMITA D,et al. Amperometric glucose sensing with polyaniline/poly(acrylic acid)composite film bearing glucose oxidase and catalase based on competitive oxygen consumption reactions[J]. Journal of Electroanalytical Chemistry,2018,811:62-67.
[43] MUTHUCHAMY N,ATCHUDAN R,EDISON T N J I,et al.High-performance glucose biosensor based on green synthesized zinc oxide nanoparticle embedded nitrogen-doped carbon sheet[J]. Journal of Electroanalytical Chemistry,2018,816:195-204.
[44] BUK V,PEMBLE M E. A highly sensitive glucose biosensor based on a micro disk array electrode design modified with carbon quantum dots and gold nanoparticles[J]. Electrochimica Acta,2019,298:97-105.
[45] AYENIMO J G,ADELOJU S B. Amperometric detection of glucose in fruit juices with polypyrrole-based biosensor with an integrated permselective layer for exclusion of interferences[J].Food Chemistry,2017,229:127-135.
[46] CHEN J H,ZHENG X Y,LI Y L,et al. A glucose biosensor based on direct electron transfer of glucose oxidase on PEDOT modified microelectrode[J]. Journal of the Electrochemical Society,2020,167(6):067502.
[47] KWAK Y H,CHOI D S,KIM Y N,et al. Flexible glucose sensor using CVD-grown graphene-based field effect transistor[J]. Biosensors and Bioelectronics,2012,37(1):82-87.
[48] JANG H,PARK Y J,CHEN X,et al. Graphene-based flexible and stretchable electronics[J]. Advanced Materials,2016,28(22):4184-4202.
[49] WANG L L,JACKMAN J A,NG W B,et al. Flexible,graphene-coated biocomposite for highly sensitive,real-time molecular detection[J]. Advanced Functional Materials,2016,26(47):8623-8630.
[50] WANG S Q,CHINNASAMY T,LIFSON M A,et al. Flexible substrate-based devices for point-of-care diagnostics[J].Trends in Biotechnology,2016,34(11):909-921.
[51] PU Z H,WANG R D,WU J W,et al. A flexible electrochemical glucose sensor with composite nanostructured surface of the working electrode[J]. Sensors and Actuators B:Chemical,2016,230:801-809.
[52] BRUEN D,DELANEY C,FLOREA L,et al. Glucose sensing for diabetes monitoring:Recent developments[J]. Sensors,2017,17(8):1866.
[53] KIM K B,LEE W C,CHO C H,et al. Continuous glucose monitoring using a microneedle array sensor coupled with a wireless signal transmitter[J]. Sensors and Actuators B:Chemical,2019,281:14-21.
[54] CENGIZ E,TAMBORLANE W V. A tale of two compartments:Interstitial versus blood glucose monitoring[J]. Diabetes Technology&Therapeutics,2009,11(Suppl 1):S11-S16.
[55] HWA K Y,SUBRAMANI B,CHANG P W,et al. Transdermal microneedle array-based sensor for real time continuous glucose monitoring[J]. International Journal of Electrochemical Science,2015,10(3):2455-2466.
[56] WANG Z J,LI H J,WANG J Q,et al. Transdermal colorimetric patch for hyperglycemia sensing in diabetic mice[J].Biomaterials,2020,237:119782.
[57] HEO Y J,TAKEUCHI S. Towards smart tattoos:Implantable biosensors for continuous glucose monitoring[J]. Advanced Healthcare Materials,2013,2(1):43-56.
[58] MCGARRAUGH G. The chemistry of commercial continuous glucose monitors[J]. Diabetes Technology&Therapeutics,2009,11(Suppl 1):S17-S24.
[59] GANI A,GRIBOK A V,RAJARAMAN S,et al. Predicting subcutaneous glucose concentration in humans:Data-driven glucose modeling[J]. IEEE Transactions on Biomedical Engineering,2009,56(2):246-254.
[60] ZHANG W,ZHANG L L,GAO H L,et al. Self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo[J]. Nano-Micro Letters,2018,10(2):1-11.
[61] ZHANG R C,LIU S Y,JIN H R,et al. Noninvasive electromagnetic wave sensing of glucose[J]. Sensors,2019,19(5):1151.
[62] YILMAZ T,FOSTER R,HAO Y. Radio-frequency and microwave techniques for non-invasive measurement of blood glucose levels[J]. Diagnostics,2019,9(1):6.
[63] KIM K O,KIM G J,KIM J H. A cellulose/β-cyclodextrin nanofiber patch as a wearable epidermal glucose sensor[J].RSC Advances,2019,9(40):22790-22794.
[64] ZHAO Y M,ZHAI Q F,DONG D S,et al. Highly stretchable and strain-insensitive fiber-based wearable electrochemical biosensor to monitor glucose in the sweat[J]. Analytical Chemistry,2019,91(10):6569-6576.
[65] YU L Y,WEI X H,FANG C,et al. A disposable biosensor for noninvasive diabetic diagnosis rest on the Au/TiO2nano-composite intensified electrochemiluminescence[J]. Electrochimica Acta,2016,211:27-35.
[66] MAKARAM P,OWENS D,ACEROS J. Trends in nanomaterial-based non-invasive diabetes sensing technologies[J]. Diagnostics(Basel,Switzerland),2014,4(2):27-46.
[67] SENIOR M. Novartis signs up for Google smart lens[J]. Nature Biotechnology,2014,32(9):856.
[68] GLIKFELD P,HINZ R S,GUY R H. Noninvasive sampling of biological fluids by iontophoresis[J]. Pharmaceutical Research,1989,6(11):988-990.
[69] TIERNEY M J,TAMADA J A,POTTS R O,et al. Clinical evaluation of the GlucoWatchRbiographer:A continual,noninvasive glucose monitor for patients with diabetes[J]. Biosensors and Bioelectronics,2001,16(9/10/11/12):621-629.
[70] KIM G J,YOON K J,KIM K O. Glucose-responsive poly(vinyl alcohol)/β-cyclodextrin hydrogel with glucose oxidase immobilization[J]. Journal of Materials Science,2019,54(19):12806-12817.
[71] KIM S K,JEON C,LEE G H,et al. Hyaluronate-gold nanoparticle/glucose oxidase complex for highly sensitive wireless noninvasive glucose sensors[J]. ACS Applied Materials&Interfaces,2019,11(40):37347-37356.
[72] CUI Y X,DUAN W,JIN Y,et al. Ratiometric fluorescent nanohybrid for noninvasive and visual monitoring of sweat glucose[J]. ACS Sensors,2020,5(7):2096-2105.
基本信息:
中图分类号:TP212.3
引用信息:
[1]刘皓,乔巨涛,方纾,等.基于葡萄糖氧化酶的葡萄糖传感器的研究进展[J],2021,40(02):43-51.
基金信息:
科技部国家重点研发计划“科技冬奥”重点专项资助项目（2019YFF0302100）;; 天津市自然科学基金资助项目（18JCYBJCL18500）